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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 1
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Research Articles

Seven new glycosides from the leaves of Datura metel L.

Jin-Yan TanKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Yan LiuKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Yan-Gang ChengKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Yan-Ping SunKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Xiao-Mao LiKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Wei GuanKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Juan PanKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaView further author information
,
Bing-You YangKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaCorrespondence[email protected]
View further author information
&
Hai-Xue KuangKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 295-304 | Received 25 Feb 2020, Accepted 30 May 2020, Published online: 15 Jun 2020
 
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Abstract

Seven new glycosides (1–7) and seventeen known analogues (8–24) were isolated from the leaves of Datura metel L. The structures of these compounds were all elucidated by detailed spectroscopic analyses and comparison with literature values. All isolates were evaluated for cytotoxicity against Hela, MGC-803, Ishikawa cell lines and compounds 6, 7, 14–17 and 24 exhibited different degrees of antiproliferative effects.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China (NSFC) (81773883 and 81903781), China Postdoctoral Science Foundation (2018M631978), Excellent Youth Project of Heilongjiang Natural Science Foundation (YQ2019H029) and Heilongjiang Postdoctoral Science Foundation (LBH-Z18245), Heilongjiang university of Chinese medicine Founds (2018pt01 and 2018bs03).

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