Abstract
Two new piericidins A5 (1) and G1 (2), a previously synthesized piericidin G2 (3), and two known piericidins A1 (4) and A2 (5) were isolated from the marine-derived Streptomyces sp. SCSIO 40063. The structures of 1-5 were elucidated by HRESIMS, 1 D, 2 D NMR data analyses and comparisons with the known compounds. Compound 2 showed moderate cytotoxicities against four human tumor cell lines SF-268, MCF-7, HepG2 and A549 with IC50 values between 10.0 and 12.7 μM.
Graphical Abstract
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Acknowledgements
We appreciate Dr. Yuchan Chen and Prof. Weimin Zhang of Guangdong Institute of Microbiology for cytotoxic activity assay. We are grateful to Zhihui Xiao, Xiaohong Zheng, Aijun Sun, Xuan Ma and Yun Zhang in the analytical facilities of SCSIO.
Disclosure statement
No potential conflict of interest was reported by the authors.