New bioactive α-pyrone from wild mushroom Paxillus involutus

Abstract

Chemical investigation of Paxillus involutus (Batsch) Fr. led to the isolation of a pair of new enantiomers (E)-5-(4-methoxy-2-oxo-2H-pyran-6-yl)pent-4-en-1-yl 2-hydroxypropanoate (1a/1b) along with 14 known compounds (2–15) for the first time from this mushroom. The structures of new compounds were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the experimental and calculated ECD data. Compounds 1a and 1b exhibited radical scavenging activities with IC₅₀ values ranging from 10.39 ± 2.26 to 20.43 ± 3.74 μg/mL. Compounds 1a and 1b also showed moderate anti-tyrosinase activity with IC₅₀ value of 25.66 ± 2.84 and 26.82 ± 3.19 μg/mL.

Graphical Abstract

Keywords:

• Paxillus involutus
• α-pyrone
• antioxidant activity
• anti-tyrosinase activity

Acknowledgments

We thank Prof. Li-an Wang at Hebei Normal University for assistance in providing experimental material.

Disclosure statement

No potential conflict of interest was reported by the authors.

Geolocation information

Changchun (E: 125.24°, N: 43.48°) is the capital of Jilin Province which located in the north of China. This region has a typical temperate continental monsoon climate with few heat resources.

Additional information

Funding

This work was supported by the National Key Research and Development Program of China under Grant [2020YFD1000304] and the National Key Research and Development Program of China under Grant [2017YFD0601002].