Two new chemical constituents from Lonicera japonica

Abstract

Two new chemical constituents, japopenoid D (1), and japopenoid E (2), were isolated and identified from the flower buds of Lonicera japonica Thunb. The structures of these compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR), and the absolute configurations of 1 and 2 were determined by comparison of their electronic circular dichroism (ECD) spectra with literature and theoretical calculation. The anti-inflammatory activities of the isolates were evaluated by measuring their inhibitory effects on PGE₂ and IL-6 production in LPS stimulated RAW 264.7 macrophages. As a result, compound 1 could reduce PGE₂ and IL-6 levels in LPS-activated RAW 264.7 macrophages with IC₅₀ values of 6.78 and 42.07 μM, respectively.

Keywords:

• Lonicera japonica thunb
• Chemical constituents
• Anti-inflammatory
• PGE₂
• IL-6

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by Jiangsu Planned Projects for Postdoctoral Research Funds and the National Standard Research of Traditional Chinese Medicine for Reduning Injection (No. ZYBZH-C-JS-31).