Three pairs of sesquiterpene enantiomers from Chloranthus multistachys pei

Abstract

Phytochemical investigation on the whole plant of Chloranthus multistachys pei (Chloranthaceae) afforded three pairs of new sesquiterpene enantiomers (+)/(−)-chlorantene M [(+)/(−)-1], (+)/(−)-chlorantene M1 [(+)/(−)-2] and (+)/(−)-chlorantene N [(+)/(−)-3]. The structures of new compounds were determined through spectroscopic techniques (HR-ESI-MS, 1 D and 2 D NMR), besides, their absolute and relative configurations were established by using Single-crystal X-ray diffraction analysis and CD spectrum. The anti-inflammatory potential of all compounds was evaluated by applying LPS induced RAW 264.7 macrophage inflammatory model, and the results were that none of these compounds showed activity (IC₅₀ > 100 μM).

Keywords:

• Chloranthus multistachys Pei
• sesquiterpene
• enantiomer
• anti-inflammatory

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially sponsored by grants from National Natural Science Foundation of China (No. 82060697) and Doctoral Research Initiation Fund of Jiangxi University of Chinese Medicine (No. 2018BSZR003).