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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 12
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Research Articles

Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity

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Pages 3085-3094 | Received 25 Mar 2021, Accepted 11 Jul 2021, Published online: 25 Oct 2021
 

Abstract

Three new biflavonoids, umcephabiovins C − E (1 − 3), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 − 3 exhibited significant α-glucosidase inhibitory activity with IC50 values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 μM, respectively. Compound 11 showed moderate cytotoxicity against the BaF3/T315I cell line.

Graphical Abstract

Disclosure statement

All the authors have no conflict of interest to declare.

Additional information

Funding

The research was supported by Guangzhou Science and Technology Innovation funding (201807010096), University of Macau (MYRG2019-00150-ICMS), National Key R&D program of China (No. 2017YFC1703802) and National Natural Science Foundation of China (No. U1801287).

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