Undescribed chalcone and stilbene constituents from Lysimachia baviensis and their anti-inflammatory effect

Abstract

The chemical composition and anti-inflammatory activity of the endemic Lysimachia baviensis were investigated for the first time in this study. A phytochemical fractionation of the methanol extract of L. baviensis resulted in the isolation of a new stilbene (bavienside A, 1) and two new chalcone glycosides (baviensides B and C, 2 and 3). Their structures were elucidated via the interpretation of NMR and HRESIMS spectroscopic data. Compounds 1–3 strongly inhibited the production of nitric oxide in LPS-induced RAW264.7 cells with the IC₅₀ values of 6.23, 2.86 and 3.51 μM, respectively. The C-acetylstilbene and carbomethyl chalcone structures in compound 1 and 3 were found for the first time from natural source and could be important markers for chemotaxonomy of Lysimachia baviensis.

Graphical Abstract

Keywords:

• Lysimachia baviensis
• Primulaceae
• C-acetylstilbene
• carbomethyl chalcone

Disclosure statement

No potential conflict of interest was reported by the authors

Additional information

Funding

This work is supported by the National Foundation for Science and Technology Development under grant code, 106.03-2018.06.