Abstract
Six globoscin derivatives (1‒6) including two new ones fischerins A (1) and B (2) were isolated from the deep-sea-derived fungus Aspergillus fischeri FS452. Their structures were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by the quantum chemical ECD calculations. The in vitro cytotoxicity assays indicated that fischerin B (2) exhibited potential activities against the four tested human cancer cell lines (SF-268, MCF-7, HepG-2 and A549) with the IC50 values in the range of 7–10 µM.
Graphical Abstract
Acknowledgements
We gratefully acknowledge support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, and thank Ai-Jun Sun, Yun Zhang and Xuan Ma, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for the measurement of HRESIMS.
Disclosure statement
The authors declare no competing financial interest.