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Abstract
Antrodia camphorata is used as a medicinal fungus in Taiwan to treat fatigue, food intoxication, and enhance liver function. Here we identified fermented metabolic components from the mycelium of A. camphorata KH37 and explored their anti-hepatoma potentials with study models of human hepatoblastoma cell lines. Bioassay-guided fractionation of the solid fermentation powder of A. camphorata KH37 led to the isolation of one new quinonol, antroquinonol Z (1), and nine known compounds (2–10). Treatment with 10 μM antrocamols LT1 (2) or LT3 (3) reduced cell viability of HepG2 and Huh-7 cells to about 60% in 48 hours. Antroquinonol Z (1) exhibited mild cytotoxicity against Huh-7 cells in 48 and 72 hours. Interestingly, two fractions showed cytotoxicity in HepG2 and Huh-7 cells, even better than compounds isolated from these fractions. The significant cytotoxicity of partially purified samples from A. camphorata KH37 exhibited a potential for developing alternative or complementary therapeutics against hepatoma.
Graphical Abstract
Acknowledgments
We are grateful to the Center for Research Resources and Development of Kaohsiung Medical University for providing the nuclear magnetic resonance (NMR) spectrometer and Chyi-Jia Wang for technical assistance in the 2D NMR experiments; the High Valued Instrument Center of National Sun Yat-sen University for providing the Fourier-transform mass spectrometry measurements.
Disclosure statement
No potential conflict of interest was reported by the authors.
Correction statement
This article was originally published with errors, which have now been corrected in the online version. Please see Correction 10.1080/14786419.2022.2088169.