One new limonoid with cytotoxicity against glioma cell lines from Cipadessa baccifera

Abstract

Glioma is a common malignant tumor with a high incidence rate but a low cure rate. In this paper, one previously undescribed limonoid (1), along with two known cipadesin-type limonoids 2 and 3, were isolated from Cipadessa baccifera. Their structures were established based on a comprehensive analysis of NMR and MS spectra. Compound 1 exhibited moderate cytotoxicity against U251 and BT-325 cells with IC₅₀ values of 7.32 ± 0.21 and 13.25 ± 0.35 μM, suggesting that 1 might be a promising leading compound for the treatment of glioma.

Graphical abstract

Keywords:

• Cipadessa baccifera (Roth) Miq.
• cytotoxicity
• U251

Acknowledgement

The authors thanks Prof. Fan He from Macau University of Science and Technology, for her kind help in determining the NMR.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.