A new neolignan and a new phenolic acid from the heartwood of Mansonia gagei J.R. Drumm

Abstract

One new neolignan (1) and one new phenolic compound (2), together with four known compounds (3–6) were isolated from the heartwood of Mansonia gagei. Their structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR and HRESIMS. The absolute configuration of 2 was established based on the DP4+ protocol and by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated by DPPH assay for antioxidant activity, while compounds 3–6 were assayed using the MTT-based colorimetric assay for cytotoxicity against lung cancer cell line A549. In terms of antioxidant activity, 1 and 3 exhibited stronger activity (IC₅₀ 14.91 ± 1.10 and 17.46 ± 0.16 μM, respectively) than the positive control, ascorbic acid (IC₅₀ 30.20 ± 0.47 μM). Among the compounds tested for cytotoxicity, compound 3 showed the highest activity, with an IC₅₀ value of 26.04 ± 2.95 µM.

Graphical Abstract

Keywords:

• Mansonia gagei
• sesquiterpenoid
• neolignan
• phenolic
• cytotoxicity
• antioxidant

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by a scholarship from the Graduate School, Chulalongkorn University to commemorate the 100th anniversary of Chulalongkorn University and the 90th Anniversary Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund). In addition, we are also indebted for support from the Thailand Research Fund via Directed Basic Research Grant (Grant no. DBG6180029) and the National Nanotechnology Center (NANOTEC), NSTDA, Ministry of Science and Technology, Thailand through its program of Research Network NANOTEC (RNN).