Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme

Abstract

Two new phenolic compounds Fusagunolics A (1) and B (2) were isolated from the plant endophytic fungus Fusarium guttiforme, in addition to the previously known metabolites (3-6). The structures of these compounds was elucidated using a combination of spectroscopic analyses, including UV, HRESIMS, 1 D, and 2 D NMR, as well as electronic circular dichroism (ECD) and the optical rotatory dispersion (ORD). Further, the anti-inflammatory activity of all the compounds was evaluated to assess their capability to inhibit nitric oxide (NO) production by RAW 264.7 macrophages. The bioactive screening revealed that compounds 2 and 6 exhibited moderate inhibitory effects against NO production with the IC₅₀ values 28.6 and 37.6 μM, respectively.

GRAPHIC ABSTRACT

Keywords:

• Fusarium guttiforme
• phenolic metabolites
• nitric oxide
• inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Natural Science Key Research Program of Anhui Province University (KJ2020A0915), Foundation of Anhui Province Key Laboratory of Research & Development of Chinese Medicine (AKLPDCM202004), Key Natural Science Foundation of Wuhu Institute of Technology (wzyzrzd202210).