Chemical constituents of Impatiens parvisepala and their α-glucosidase inhibition activity

Abstract

The first chemical study of the whole Impatiens parvisepala S. X. Yu & Y. T. Hou led to the isolation of a new triterpene saponin, named Iparvisepala-1 (6) along with ten known compounds, which cover three flavonoid glycosides (1-3), one dihydrochalcone glucoside (4), one triterpenoid saponin (5), one triterpene (7) and four miscellaneous compounds (8-11). Their structures were elucidated by MS, NMR spectroscopic analyses as well as by comparisons of spectra data with those of the related published literatures. Additionally, flavonoid glucoside 2 showed impressive effect on α-glucosidase inhibition with the IC₅₀ value of 12.53 ± 0.39 µM, much better than that of the positive control acabose (IC₅₀ = 197.53 ± 2.68 µM).

Graphical Abstract

Keywords:

• Impatiens parvisepala
• Balsaminaceae
• triterpenoid saponin
• flavonoid glycoside
• α-glucosidase inhibition

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors wish to thank the National Foundation for Science and Technology Development of Vietnam (NAFOSTED) for financial support (Project code 104.01-2018.339). One of us, Nguyen Thi Thuy Linh acknowledges financial support by the Ph.D. Scholaship of Vingroup Innovation Foundation (Code VINIF.2021.TS.071).