Abstract
Dysoxyllum binectariferum is an important medicinal plant known for various biological activities like anti-inflammatory, CNS depressants, contraceptive, analgesic, immunomodulatory, antimalarial, antifeedant, leishmanicidal and antiviral. It is a rich source of rohitukine, a basic skeleton of flavopiridol. Phytochemical investigation of chloroform extracts of Dysoxyllum binectariferum leaves, lead to the isolation of beddomeilactone (1) and two new cycloartane type triterpenoids beddomeilactol (2) and binectarilactone-A (3) with modified A ring. Compounds were assessed for their in-vitro α-glucosidase inhibitory activity. Compound 1 was found to be most potent, showing IC50 of 17.99 ± 0.26 µg/ml which is comparable to the positive control acarbose.
Acknowledgments
CPS thanks CSIR, Govt. of India, for providing fellowship, and all authors acknowledged for funding CSIR-Phytopharma mission-II (HCP-038). We also acknowledged the Director CSIR-IIIM Jammu for providing laboratory facilities and Dr. Sandip B. Bharate for his valuable suggestions. IIIM Publication Number: CSIR-IIIM/IPR/00496.
Disclosure statement
No potential conflict of interest was reported by the authors.