![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
A new chromone derivative, aspergione A (1), along with seven known metabolites, was isolated from a mangrove endophytic fungus, Aspergillus sp. GXNU-B1, which was collected from mangrove Acanthus ilicifolius L. Their structures and the absolute configuration of 1 were elucidated based on the analysis of HR-ESI-MS, NMR, and ECD calculation. Compounds 1-8 were evaluated for their anti-inflammatory effects on the production of nitricoxide (NO). Compounds 1 and 8 have potent inhibitory effects against NO production in activated macrophages with IC50 values of 38.26 and 44.30 μM, respectively.
Graphical Abstract
Disclosure statement
The authors declare no conflict of interest.
Additional information
Funding
The authors (J.G. Huang. and X.S. Huang) acknowledge the following agencies for funding this project: Department of Science and Technology of Guangzhou under grant number 202102020608/2021KTSCX200. National Natural Science Foundation of China (42066005); the Natural Science Foundation of Guangxi Province (2020JJA150036); Guangxi Science and Technology Base Special Talents (2019AC20095).