Polybrominated diphenyl ethers isolated from the marine sponge Lendenfeldia chondrodes collected in Mayotte

Abstract

CDK7 and FynB protein kinases have been recognized as relevant targets for cancer and brain diseases treatment due to their pivotal regulatory roles in cellular functions such as cell cycle and neural signal transduction. Several studies demonstrated that the inhibition of these proteins could be useful in altering the onset or progression of these diseases. Based on bioassay-guided approach, the extract of the marine sponge Lendenfeldia chondrodes (Thorectidae), which exhibited interesting kinase inhibitory activities, was fractionated. The investigation led to the isolation of five known 1–5 and one new 6 polybrominated diphenyl ethers (PBDEs). Their structure elucidation was established based on spectroscopic data (NMR and HRMS) and comparison with literature data.

Graphical Abstract

Keywords:

• Marine sponge
• Lendenfeldia chondrodes
• polybrominated diphenyl ethers
• PBDE
• kinase inhibitory activity

Acknowledgements

The authors acknowledge the contribution of Crelux GmbH (https://www.crelux.com/), Am Klopferspitz 19a, 82152 Martinsried, Germany for bioassays (CDK7, FynB) methodology and validation.

Authors’ contribution

Conceptualization, A.G.-B., J.O.; supervision, A.G.-B, M.F., L.D.; chemical investigations (extraction, isolation, and structural identification of the compounds), F.T., P.-E.C. and G.H; bioassays methodology and validation, Crelux; sponge identification, N.J.d.V.; writing—original draft preparation, C.S.H.; writing—review and editing, C.S.H, A.G.-B, P.-E.C, L.D, G.H, N.dV. All authors have read and agreed to the published version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project was supported by the Regional Council of Reunion Island and the TASCMAR project which is funded by the European Union under grant agreement number 634674.