http://orcid.org/0000-0001-8070-8786
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ABSTRACT
Background: We aimed to evaluate the efficacy of five oral nucleos(t)ide analogues (NAs), including lamivudine, entecavir, adefovir, telbivudine and tenofovir, for the prevention of hepatitis B virus (HBV) reactivation and HBV-related complications in chronic hepatitis B virus (CHB) infected patients with hematological malignancies receiving chemotherapy or hematopoietic stem cell transplantation (HSCT) by network meta-analysis.
Methods: The search identified 28 articles involving 5 different prophylactic regimens covering 1478 participants.
Results: Among five prophylactic regimes, tenofovir (predicted probability, 90%), was the most effective intervention followed by entecavir (88%) in preventing HBV reactivation. There was no significant difference between tenofovir and entecavir for preventing HBV reactivation. With regards to other outcomes, tenofovir and telbivudine was not included to evaluate due to lack of relevant studies. Entecavir was the most effective intervention in reducing the risk of HBV related hepatitis (100%), HBV related death (61%) and all other causes of hepatitis (98%).
Conclusion: Tenofovir and entecavir might be the most potent regimes in prevention of HBV reactivation for CHB infected patients with hematological malignancies undergoing chemotherapy or HSCT.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
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Notes on contributors
Min-Yue Zhang
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Gui-Qi Zhu
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Ji-Na Zheng
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Zhang Cheng
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Sven Van Poucke
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Ke-Qing Shi
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Hong-Hui Huang
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Fang-Yuan Chen
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.
Ming-Hua Zheng
Author contributions: Zhang MY, Zhu GQ, Shi KQ, Chen FY and Zheng MH designed the study. Zhang MY, Zhu GQ, Huang HH screened studies and extracted data. Zhu GQ and Zheng JN did the statistical analyses. Cheng Z prepared figures. Zhang MY, Zhu GQ, Poucke SV, Huang HH, Chen FY and Zheng MH reviewed the results, interpreted data, and wrote the manuscript. All authors saw and approved the final version of the paper.