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Expert Review of Anti-infective Therapy Volume 19, 2021 - Issue 6
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Editorial

Potential role of glycoprotein 340 in milder SARS-CoV-2 infection in children

Mohammad Zareia Center of Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;b Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USAView further author information
,
Deepanwita Bosec Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Boston, MA, USA;d Harvard Medical School, Boston, Massachusetts, USAView further author information
,
Soheila Ali Akbari Ghavimie Department of Surgery, Division of Otolaryngology, Children’s Hospital of Philadelphia, Philadelphia, PAUSAView further author information
,
Masoud Nouri-Vaskehf Immunology and Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranView further author information
,
Mehdi Mohammadig Department of Biological Sciences, University of Calgary, Calgary, Alberta, CanadaView further author information
&
Amirhossein Sahebkarh Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;i Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;j Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, PolandCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-8656-1444View further author information
ORCID Icon
Pages 675-677 | Received 23 Sep 2020, Accepted 10 Nov 2020, Published online: 14 Jan 2021

Figures & data

Figure 1. Schematic diagram of the binding of GP-340 to spike protein of SARS-CoV-2 in children and adults. Children have higher GP-340 along with lower ACE-2 receptors. GP-340 targets spike protein’s glycoprotein-binding domains (GBD) and blocks virus adherence or entry of SARS-CoV-2

Figure 1. Schematic diagram of the binding of GP-340 to spike protein of SARS-CoV-2 in children and adults. Children have higher GP-340 along with lower ACE-2 receptors. GP-340 targets spike protein’s glycoprotein-binding domains (GBD) and blocks virus adherence or entry of SARS-CoV-2

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