Figures & data
Figure 1. Steps from biomarker discovery to clinical implementation. The image was created in BioRender.
![Figure 1. Steps from biomarker discovery to clinical implementation. The image was created in BioRender.](/cms/asset/b668ae80-2886-429e-92a7-42cb56dfc4b7/ieru_a_2343585_f0001_oc.jpg)
Figure 2. Main characteristics of saliva as biofluid and types of devices for saliva collection. The image was created with the BioRender.
![Figure 2. Main characteristics of saliva as biofluid and types of devices for saliva collection. The image was created with the BioRender.](/cms/asset/cb0be419-4308-4cb2-a184-70f0784f050a/ieru_a_2343585_f0002_oc.jpg)
Figure 3. Proteomics workflow and most used experimental approaches in proteomic studies using saliva as liquid biopsy for oral cancer. This image was created in BioRender.
![Figure 3. Proteomics workflow and most used experimental approaches in proteomic studies using saliva as liquid biopsy for oral cancer. This image was created in BioRender.](/cms/asset/205e4446-d27b-4e45-aa63-12fd1412c7c0/ieru_a_2343585_f0003_oc.jpg)
Table 1. Salivary biomarkers for oral cancer and the main techniques used in each study.
Figure 4. Temporal evolution of salivary biomarkers and techniques used in its identification. Vosviewer network of most cited salivary biomarkers and techniques used in proteomics for biomarkers discovery in oral cancer (a). Vosviewer overlay showing the temporal distribution of the most cited salivary biomarkers and techniques used in proteomics for biomarkers discovery in oral cancer (b). Chronological discovery of the most relevant techniques used in studies of proteomics using saliva as source of liquid biopsy for discovery of biomarkers of oral cancer (c).
![Figure 4. Temporal evolution of salivary biomarkers and techniques used in its identification. Vosviewer network of most cited salivary biomarkers and techniques used in proteomics for biomarkers discovery in oral cancer (a). Vosviewer overlay showing the temporal distribution of the most cited salivary biomarkers and techniques used in proteomics for biomarkers discovery in oral cancer (b). Chronological discovery of the most relevant techniques used in studies of proteomics using saliva as source of liquid biopsy for discovery of biomarkers of oral cancer (c).](/cms/asset/c4461240-32ac-4bd8-89c7-846f303ca0cf/ieru_a_2343585_f0004_oc.jpg)