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Abstract
Objective: A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRRβ) showed possible association to noise-induced hearing loss (NIHL) in our previous study. Design: This study was conducted to examine the effect of the ESRRβ rs61742642 T variant on temporary threshold shift (TTS). TTS was induced by 10 minutes of exposure to audiometric narrow-band noise centered at 2000 Hz. Hearing thresholds and distortion product otoacoustic emissions input output function (DP IO) at 2000, 3000, and 4000 Hz were measured before and after the noise exposure. Study sample: Nineteen participants with rs61742642 CT genotype and 40 participants with rs61742642 CC genotype were recruited for the study. Results: Participants with the CT genotype acquired a significantly greater TTS without convincing evidence of greater DP IO temporary level shift (DPTLS) compared to participants with the CC genotype. Conclusion: The results indicated that the ESRRβ polymorphism is associated with TTS. Future studies were recommended to explore molecular pathways leading to increased susceptibility to NIHL.
Acknowledgements
This work is supported by the Theodore and Loretta Williams Graduate Research Award Fund for Arts Health (2012). We also thank the Music Research Institute and the Center for Biotechnology, Genomics, and Health Research for their support. We also acknowledge the assistance of David Kemp for OAE methodology development, Sandra Teglas and Donald Hodges with data collection, Jenna Callendar and Renuka Shivaji for technical assistance with the preparation and processing of DNA samples.
Declaration of interest
The authors declare no conflicts of interest.