MOLAR GESTATIONS AND HYDROPIC ABORTIONS DIFFERENTIATED BY p57 IMMUNOSTAINING

Figures & data

TABLE 1. Summary of Clinical Information and Pathologic Diagnoses Based on ConventionalHistology and Immunohistochemistry

Clinical Diagnosis	Number of Cases	Pathologic Diagnosis	Original Diagnosis H&E	Revised Diagnosis with p57
Abortion	35 (41%)	Hydropic	42 (49%)	45 (52%)
Hydatidiform mole	46 (53%)	Partial mole	21 (24%)	15 (37%)
Undetermined	5 (6%)	Complete mole	23 (27%)	26 (63%)
Total	86 (100%)	Total	86 (100%)	86 (100%)

Figure 1. Very early hydropic abortion at 10 × lens (A and B) and 20 × lens (C and D) hematoxylin and eosin stain (A and C) and positive staining for p57 (B and D) in the cytotrophoblast, mesenchymal cells, and intermediate trophoblast.

Figure 2. Partial mole at 10 × lens (A and B) and 20 × lens (C and D) show the hematoxylin and eosin stain (A and C) and focal positivity for p57 (B and D) in the cytotrophoblast but not the mesenchyme. The intermediate trophoblast is focally positive.

Figure 3. Complete mole is seen at 10 × lens (A and B) and 20 × lens (C and D) hematoxylin and eosin stain (A and C). There is no p57 staining (B and D) in the cytotrophoblast or in the intermediate trophoblast.

TABLE 2. Diagnosis and Clinical Outcome

H&E Diagnosis	p57 Diagnosis	Cases with Persistent Trophoblastic Disease
Complete mole	Complete mole	4
Partial mole	Partial mole	2
Partial mole	Complete mole	4
Hydropic abortion	Partial mole	1
Total		11

*One case developed choriocarcinoma.

Figure 4. Recommended diagnostic approach to hydropic abortions and hydatidiform moles.