Synthesis and Antiviral Properties of Aza-Analogues of Acyclovir

Abstract

Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.

Keywords:

• Antiviral agents
• Acyclic nucleosides
• Aza-nucleosides
• Acyclovir analogues

This work was financially supported by Warsaw University of Technology. We thank Leentje Persoons, Frieda De Meyer and Anita Van Lierde for excellent technical assistance with the antiviral assays.