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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 4
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Original Articles

Short Synthesis And Antiviral Evaluation Of c-Fluoro-Branched Cyclopropyl Nucleosides

Chang Hyun Oh Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea and BK21 Project Team, College of Pharmacy, Chosun University, Kwangju, Republic of Korea
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Joon Hee Hong Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea and BK21 Project Team, College of Pharmacy, Chosun University, Kwangju, Republic of Korea
Pages 403-411 | Received 11 Aug 2006, Accepted 24 Jan 2007, Published online: 03 May 2007
 
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A series of novel fluorocyclopropyl nucleosides were synthesized using the Simmons-Smith reaction as a key reaction starting from 1,3-dihydroxyacetone. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the 5-fluorouracil analogue 15 showed significant anti-HCMV activity (9.22 μM).

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