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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 6-7
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Original Articles

Synthesis and Antitumor Activity of Fluorocyclopentenyl-Pyrimidines

Lak Shin Jeong College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Long Xuan Zhao College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Won Jun Choi College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Shantanu Pal College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Yeon Hee Park College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Sang Kook Lee College of Pharmacy, Ewha Womans University, Seoul, Korea
,
Moon Woo Chun College of Pharmacy, Seoul National University, Seoul, Korea
,
Young B. Lee Rexahn Corporation, Rockville, Maryland, USA
,
Chang Ho Ahn Rexahn Corporation, Rockville, Maryland, USA
&
Hyung Ryong Moon College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Korea
 show all
Pages 713-716 | Published online: 10 Dec 2007
 
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Abstract

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6–9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

Acknowledgments

This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502).

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