Different Strategies for the Synthesis of 2′-O-Aminoethyl Adenosine Building Blocks

Abstract

The chemical modification of the 2′-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we investigated the synthesis of 2′-O-aminoethyl adenosine as a cationic modified building block.

Keywords:

• 2′-O-position
• RNA stability
• building blocks

Acknowledgments

We would like to thank the “Sonderforschungsbereich 579” and the RIGHT EU-Project NoLSHB-CT-2004-005276 for financial support.