Investigation of Novel Lipid-Functionalized PNA Monomers as Potential HIV-1 Non-Nucleoside Reverse Transcriptase and/or Integrase Inhibitors

Abstract

A range of novel N-terminal lipid-functionalized peptide nucleic acid (PNA) monomers have been prepared and their abilities to inhibit HIV-1 reverse transcriptase and integrase have been examined.

Keywords:

• Anti-HIV agents
• non-nucleoside reverse transcriptase inhibitors
• integrase inhibitors
• PNA analogues

Acknowledgments

This work was supported by the EU FP6 IP grant “Targeting Replication and Integration of HIV” (TRIoH, LSHB-CT-2003-503480).