Synthesis, Spectral Characterization, and Biological Activity of Some New Substituted 10H-Phenothiazines, Its Ribofuranosides, and Sulfones

Abstract

This article describes the synthesis of new substituted 10 H-phenothiazines by Smiles rearrangement. These compounds are then used as a base to form ribofuranosides by treating them with a sugar (1-O-acetyl-2,3,5-tri-O-benzoyl-β-ribofuranose). On oxidation with hydrogen peroxide in glacial acetic acid, these phenothiazines yield their sulfones. These compounds are screened for antioxidant and antimicrobial activity and their structure has been established by elemental analysis and spectroscopic data.

Keywords:

• Smiles rearrangement
• ribofuranosides
• antioxidant and antimicrobial activity

The authors are grateful to the Department of Chemistry, University of Rajasthan, Jaipur for providing necessary facilities. UGC Research Award Scheme and UGC (New Delhi) are duly acknowledged for financial support.

Notes

∗The assay was carried out in triplicate and the percentage of inhibition was calculated using the following formula:% inhibition = (AB−AA) × 100/ AB, where, AB = absorption of blank; AA = absorption of test.