Current and emerging EGFR therapies for glioblastoma

ABSTRACT

Glioblastomas (GBMs) are the most lethal and hard to treat malignancies in clinical practice. The standard of care for treating GBM involving surgery and adjuvant radiotherapy and concomitant temozolomide (TMZ) has remained virtually unchanged in the past decade. Molecular targeted therapies against cancer-specific structures have reported mediocre results in the treatment of GBM, due to multiple factors such as the presence of the blood brain barrier or a vast array of molecular alterations which greatly hinder the action of the most therapeutic agents. One such therapy is directed against the epidermal growth factor (EGF) and its’ receptor (EGFR) using either monoclonal antibodies or tyrosine kinase inhibitors. Even though anti-EGF/EGFR treatment produced encouraging results in other forms of cancer it failed to present any clinical benefit for patients with GBM. Lately, immunotherapies that focus on using the host’s own immune system against cancer cells have gained popularity, with approaches like peptide vaccination being successfully used in clinical trials for different types of malignancies. These immune-based therapies could hold the key to improving both the prognosis and quality of life for patients suffering for cancers previously considered incurable, such as GBM.

KEYWORDS:

• EGFR
• glioblastoma
• tyrosine kinase
• targeted therapy
• immunotherapy

Acknowledgment

Executive Agency for Higher Education, Research, Development and Innovation Funding Romania (UEFISCDI) PN-II-ID-PCE-2011-3-1041

Additional information

Funding

This work was supported by The Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) Romania. Grant No. PN-II-ID-PCE-2011-3-1041.