Abstract
Addiction is a multifaceted problem with complex etiology, calling for a multidimensional treatment approach. This article explores the interface of regulation theory and the self-medication hypothesis (SMH) and applies clinical strategies based on regulation theory to the treatment of substance addiction. Specifically, this article argues that treatment informed by regulation theory supports the development of an individual’s capacity for self-regulation, thereby targeting the dysregulation identified by the SMH as an underlying cause of addictive behaviors. This approach offers a viable framework for addiction treatment. Implications for clinical practice and further research are also explored.