8p deletion is strongly linked to poor prognosis in breast cancer

Figures & data

Table 1. Clinico-pathological association of 8p deletion

				8p FISH
		On TMA (n)	Analyzable (n)	normal	deletion	P value
All cancers		2197	1248	52%	48%
Histology	No special type	1531	919	50%	50%	—
	Lobular carcinoma	311	126	63%	37%	0.006^**
	Cribriform carcinoma	64	41	61%	39%	0.20
	Medullary carcinoma	57	39	44%	56%	0.42
	Tubular carcinoma	56	29	72%	28%	0.02
	Papillary carcinoma	30	18	33%	67%	0.16
	Mucinous carcinoma	69	35	69%	31%	0.04
	Other rare types^*	79	41	37%	63%	0.11
pT stage	pT1	804	402	59%	41%	<0.0001
	pT2	1015	626	51%	49%
	pT3	124	66	30%	70%
	pT4	242	147	46%	54%
BRE grade	Grade 1	539	290	68%	32%	<0.0001
	Grade 2	839	438	57%	43%
	Grade 3	646	427	35%	65%
Nodal stage	pN0	936	524	55%	45%	0.006
	pN1	783	449	49%	51%
	pN2	121	72	38%	63%
ER status	Negative	474	296	43%	57%	0.0001
	Positive	1544	905	55%	45%
PR status	Negative	1265	743	50%	50%	0.25
	Positive	661	414	54%	46%

* Including adenoid-cystic carcinoma, apocrine carcinoma, atypical medullary carcinoma, carcinosarcoma, clear cell carcinoma, histiocytic carcinoma, lipid rich carcinoma, lipid rich or histiocytoic carcinoma, metaplastic carcinoma, neuroendocrine carcinoma, signet ring carcinoma, and small cell carcinoma.

** Versus cancers of no special type.

Figure 1. Examples of FISH findings using the 8p deletion probe. (A) Heterozygous deletion as indicated by the lack of one orange 8p signal. (B) Normal 8p copy numbers as indicated by 2 orange 8p signals and 2 green centromere 8 signals.

Figure 2. Associations between 8p status and amplifications of HER2, MYC, and CCND1 analyzed by FISH.

Figure 3. Association between 8p deletion and Ki67-labeling index. (A) all cancers, (B) Grade 1 cancers, (C) Grade 2 cancers, and (D) Grade 3 cancers.

Figure 4. Association between 8p deletion and raw survival. (A) all cancers (n = 1,246), (B) no specific type cancers (n = 917), and (C) no specific type and pN positive cancers (n = 406).