Effective treatment of aggressive fibromatosis with celecoxib guided by genetic testing

Figures & data

Figure 1. Tumor on the chest wall before surgery.

Figure 2. MRI demonstrates thickened soft tissue lesion four months after surgery.

Figure 3. Tumor remarkable shrinkage was confirmed. PET-CT before the commencement of celecoxib on April 2014 A. CT scan on November 2015 B. and on October 2016 C. showed that tumor was smaller after using celecoxib.

Table 1. Result of gene mutation. CTNNB1 gene codes β-catenin, a kind of adhesive connections protein. ARID1B gene could code protein, playing an important role in cell cycle activation. The protein coded by SMC3 gene could be the kernel protein or secretory protein in specific cells. MSH5 gene codes mutS protein family, participating in DNA mismatch repair and meiotic recombination.

Gene	Base mutation	Amino acid mutation	Mutation frequency
CTNNB1	c.[121A>G]	p.[T41A]	4%
ARID1B	c.[811G>T]	p.[A271S]	2.04%
SMC3	c.[170G>A]	p.[R57H]	2.11%
MSH5	c.[136_138delGAG]	p.[E46del]	3.94%