1,322
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

Remarkable response with pembrolizumab plus albumin-bound paclitaxel in 2 cases of HER2-positive metastatic breast cancer who have failed to multi-anti-HER2 targeted therapy

, , , , , & show all
Pages 292-295 | Received 15 Aug 2017, Accepted 05 Dec 2017, Published online: 18 Jan 2018

Figures & data

Figure 1. In case 1, CT images showed a continuously increase of the lung metastases during multi-anti-HER2 targeted therapy and a remarkable decrease after treatment of pembrolizumab plus albumin-bound paclitaxel with the reduction of serum HER2 ECD levels.

Figure 1. In case 1, CT images showed a continuously increase of the lung metastases during multi-anti-HER2 targeted therapy and a remarkable decrease after treatment of pembrolizumab plus albumin-bound paclitaxel with the reduction of serum HER2 ECD levels.

Figure 2. In case 2, CT images showed a continuously increase of the right chest wall metastasis during multi-anti-HER2 targeted therapy and a remarkable decrease after treatment of pembrolizumab plus albumin-bound paclitaxel with the reduction of serum HER2 ECD levels.

Figure 2. In case 2, CT images showed a continuously increase of the right chest wall metastasis during multi-anti-HER2 targeted therapy and a remarkable decrease after treatment of pembrolizumab plus albumin-bound paclitaxel with the reduction of serum HER2 ECD levels.

Figure 3. The immunohistochemistry results showed PD-Ll and PD-1 expression of the tumor sample (formalin-fixed paraffm-embedded specimens) obtained from Case 1 patient with a proportion score of less than 1% (A and B), from Case 2 patient also with a proportion score of less than 1% (C and D) at a magnification of 200.

Figure 3. The immunohistochemistry results showed PD-Ll and PD-1 expression of the tumor sample (formalin-fixed paraffm-embedded specimens) obtained from Case 1 patient with a proportion score of less than 1% (A and B), from Case 2 patient also with a proportion score of less than 1% (C and D) at a magnification of 200.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.