Association between genetic variants in p53 binding sites and risks of osteosarcoma in a Chinese population: a two-stage case-control study

Figures & data

Table 1 Demographic characteristics of OS cases and healthy controls.

	Stage 1			Stage 2
	Cases (n = 500)	Controls (n = 500)	P value	Cases (n = 800)	Controls (n = 800)	P value
Age
≤20	276 (55.2%)	270 (54.0%)	0.703	462 (57.8%)	472 (59.0%)	0.612
>20	224 (44.8%)	230 (46.0%)		338 (42.2%)	328 (41.0%)
Gender
Male	277 (55.4%)	269 (53.8%)	0.611	413 (51.6%)	406 (50.8%)	0.726
Female	223 (44.6%)	231 (46.2%)		387 (48.4%)	394 (49.2%)
Family history of cancer
Yes	112 (22.4%)	36 (7.2%)	P<0.001	148 (18.5%)	68 (8.5%)	P<0.001
No	388 (77.6%)	464 (92.8%)		652 (81.5%)	732 (91.5%)
Tumor location
Long tubular bones	406 (81.2%)			635 (79.4%)
Axial skeleton	94 (18.8%)			165 (20.6%)
Enneking stages
I	52 (10.4%)			72 (9.0%)
II	375 (75.0%)			588 (73.5%)
III	73 (14.6%)			140 (17.5%)

Table 2. Associations between candidate SNPs and OS susceptibility in stage I

Genetic model	Cases	Controls	OR (95% CI) ^a	P value
rs3787547
GG	217	254	Reference
AG	219	195	1.37 (1.02-1.82)	0.034
AA	64	51	1.53 (0.99-2.35)	0.053
A vs G			1.31 (1.06-1.61)	0.012
rs290392
AA	164	176	Reference
AG	259	241	1.15 (0.87-1.51)	0.310
GG	77	83	0.99 (0.68-1.45)	0.982
G vs A			1.02 (0.86-1.23)	0.785
rs1295925
TT	186	151	Reference
CT	221	241	0.74 (0.56-0.99)	0.040
CC	93	108	0.70 (0.49-0.99)	0.045
C vs T			0.81 (0.68-0.97)	0.024

a Adjusted for age, gender, and family history of cancer

Table 3. Associations between candidate SNPs and OS susceptibility in stage II

Genetic model	Cases	Controls	OR (95% CI) ^a	P value
rs3787547
Stage II
GG	353	400	Reference
AG	347	318	1.29 (1.02-1.63)	0.037
AA	99	82	1.42 (1.00-2.02)	0.047
A vs G			1.25 (1.05-1.48)	0.011
Pooled results
GG	570	654	Reference
AG	566	513	1.32 (1.10-1.58)	0.003
AA	163	133	1.46 (1.11-1.92)	0.006
A vs G			1.27 (1.11-1.45)	4.0 × 10^−4
rs1295925
Stage II
TT	290	248	Reference
CT	362	390	0.79 (0.63-0.99)	0.041
CC	148	162	0.78 (0.59-1.03)	0.084
C vs T			0.87 (0.75-0.99)	0.045
Pooled results
TT	476	399	Reference
CT	583	631	0.77 (0.65-0.92)	0.004
CC	241	270	0.75 (0.60-0.93)	0.009
C vs T			0.85 (0.76-0.94)	0.003

a Adjusted for age, gender, and family history of cancer