The functional roles of exosomes-derived long non-coding RNA in human cancer

Figures & data

Table 1. Tumor-derived exosomal lncRNAs in human cancer.

Origin of tumor	lncRNA	Regulation	Biological function	Refs.
Cervical cancer	MALAT1	up	For the detection and diagnosis in the clinic	^Citation29,Citation94
	HOTAIR	up		^Citation30,Citation94
	MEG3	up		^Citation31,Citation94
Colorectal cancer (serum)	CRNDE-h	up	Serve as a prognostic predictor in the clinic	^Citation90
Glioma cancer	lincPOU3F3	up	Promote angiogenesis	^Citation73
Gastric cancer	ZFAS1	up	Enhance cell cycle progression, proliferation and migration	^Citation82
Breast cancer, bladder cancer	UCA1	up	Enhance drug resistance, facilitate tumor growth, for the diagnostic biomarker	^Citation70,Citation99
HCC	lincVLDLR	up	Increase cancer cell drug resistance	^Citation101
	lincROR	up	Enhance chemoresistance, promote cell survival	^Citation102,Citation103
	TUC339	up	Promote cancer cell growth and adhesion	^Citation69
Pancreatic cancer	ENST00000560647	up	Increase dendritic cell immune escape	^Citation84
HCV-induced HCC (serum)	HEIH	up	For the detection and diagnosis in the clinic	^Citation93
Non-small lung cancer	MALAT-1	up	Promote tumor growth and migration, for the diagnostic biomarker	^Citation65
Colorectal cancer (serum)	BCAR4	up	For the detection and diagnosis in the clinic	^Citation14
Renal cell carcinoma	ARSR	up	Promote agents resistance	^Citation104
Bladder cancer	HOTAIR	up	Increase cancer cells migration and invasion	^Citation98
Colon cancer(CRC)	ZFAS1	up	For the detection and diagnosis in the clinic	^Citation91
	SNHGs	up	For the detection and diagnosis in the clinic
Epithelial ovarian cancer	ENST00000444164	up	Reverse tumor-related immune response	^Citation86
	ENST0000043768	up	Reverse tumor-related immune response
Lung cancer	HMlincRNA1636+	up	9.1% of lncRNAs (2775 out of 30586) were differentially expressed upon treatment with lung tumor cell exosome	^Citation66
	NR_046464	up
	NR_052024	up
	ENST00000420309	up
	NR_046466	up
	NR_045370	up
	NR_024596	up
	ENST00000520714	up
	uc010hbj.3	up
	ENST00000440436	up
	ENST00000428453	down
	ENST00000426501	down
	TCONS_00006633	down
	ENST00000440714	down
	uc010ciy.1	down
	NR_048550	down
	uc011aef.2	down
	uc002rwa.2	down
	ENST00000488190	down
	Cb112975	down
CD90+ liver cancer	H19	up	Promote angiogenesis	^Citation76
Prostate cancer	P21	up	For the detection and diagnosis in the clinic	^Citation97

Figure 1. Exosomal lncRNA-mediated intercellular cross-talk within the tumor microenvironment. Exosomes are released into the extracellular environment and carry lncRNAs between tumor cells and surrounding microenvironment to expedite tumor progression by promoting angiogenesis, immune escape or drug resistance. Moreover, aberrant exosomal lncRNAs provide potential biomarkers for cancer diagnosis and prognosis.

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