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Cancer Biology & Therapy Volume 20, 2019 - Issue 8
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Review

Life and death of circulating cell-free DNA

Anatoli KustanovichSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelCorrespondence[email protected]
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,
Ruth SchwartzSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelView further author information
,
Tamar PeretzSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelView further author information
&
Albert GrinshpunSharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelView further author information
Pages 1057-1067 | Received 28 Nov 2018, Accepted 12 Mar 2019, Published online: 16 Apr 2019

Figures & data

Figure 1. Cell-free circulating DNA life-cycle.

The three main components of cfDNA life are presented: release, biological activity, and clearance. The figure summarizes the well-described mechanisms of each component. Although in most clinical settings naked nuclear cfDNA is analyzed, it travels in various forms in body fluids: free, inside exosomes, bound to histones (nucleosomes), protected by transcriptional factors or are as part of immune-related components (such as NETs).cfDNA is not a passive biomarker of pathophysiological conditions, but plays an active role in multiple processes such as inflammation, immunomodulation, tumor growth promotion, etc..
Figure 1. Cell-free circulating DNA life-cycle.

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