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Cancer Biology & Therapy Volume 21, 2020 - Issue 8
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Research Paper

Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells

Shengping Mina Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Xiaoxu Wanga Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Qianyu Dub Department of Medical Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
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Huiyuan Gongc Department of Thoracic Surgery, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Yan Yangb Department of Medical Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaORCID Iconhttps://orcid.org/0000-0003-0887-2770View further author information
ORCID Icon,
Tao Wanga Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Nan Wua Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Xincheng Liua Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Wei Lia Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Chengling Zhaoa Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Yuanbing Shena Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
,
Yuqing Chena Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaView further author information
&
Xiaojing Wanga Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, ChinaCorrespondence[email protected]
View further author information
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Pages 698-708 | Received 08 Jan 2019, Accepted 11 Apr 2020, Published online: 03 Jun 2020

Figures & data

Figure 1. Chetomin is an inhibitor of Hsp90/HIF1α pathway activity.

Figure 1. Chetomin is an inhibitor of Hsp90/HIF1α pathway activity.

Figure 2. Chetomin exerts its inhibitory action on NSCLC CSCs by eliciting apoptosis.

Figure 2. Chetomin exerts its inhibitory action on NSCLC CSCs by eliciting apoptosis.

Figure 3. Chetomin exerts its inhibitory action on NSCLC non-CSCs by eliciting apoptosis.

Figure 3. Chetomin exerts its inhibitory action on NSCLC non-CSCs by eliciting apoptosis.

Figure 4. Chetomin inhibits lung tumorigenesis in NSCLC mouse models.

Figure 4. Chetomin inhibits lung tumorigenesis in NSCLC mouse models.

Figure 5. Chetomin blocks Hsp90’s binding to HIF1α’s N-terminus.

Figure 5. Chetomin blocks Hsp90’s binding to HIF1α’s N-terminus.
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