Figure 1. A scheme depicting the perturbed anandamide pathway in mantle cell lymphoma. Red arrows show altered expression pattern in MCL, blue arrows show proposed effects. Altered expression of NAPE-PLD, an enzyme participating in anandamide synthesis from phospholipids, and FAAH, degrading anandamide, suggest accumulation of anandamide and together with overexpressed cannabinoid receptors, enhanced endocannabinoid signaling.
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