Figure 1. Hypoxia induced HIF-1 heterodimer complexes regulate the expression of HIF-1 target genes under hypoxia. In PITX1 overexpressing cells only a certain subset of HIF-1 dependent genes shows increased expression, here JMJD 2B, while classical HIF-1 target genes are not affected (PHD3, CA9, GLUT1) or even reduced (JMJD2C).
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