Figures & data
Figure 1. Mad1 localizes to the Golgi where it regulates secretion of α5 integrin and cell migration. (Left) Unlike Mad1 localization to the nucleus and nuclear envelope, the localization of Mad1 on the Golgi is independent of Mad2. Golgi-associated Mad1 facilitates the secretion of α5-integrin, which along with its binding partner β1-integrin, forms the cell surface receptor for the extracellular matrix (ECM) protein fibronectin. (Right) Down-regulation of Mad1 causes accumulation of α5-integrin in the Golgi and decreases cell surface localization of α5-integrin and migration on fibronectin.
