Figures & data
Figure 1. Model for vascular regulation of SVZ neurogenesis. Juxtacrine signals and paracrine factors from vascular endothelial cells (Ephrin-B2, Jagged-1, NT-3) cooperate with cell-intrinsic programs to maintain type-B cells in a quiescent and undifferentiated state in which they are refractory to proliferative cues. In contrast, activated type-B cells and their type-C progeny sense and respond to paracrine vascular cues, which promote their proliferation and neuronal differentiation into type-A cells (PEDF, BTC, BDNF). Paracrine factors such as BDNF and SDF1 induce Type-A neuroblast migration along blood vessels to the olfactory bulb.
