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EDITORIALS: CELL CYCLE FEATURES

LKB1 regulates germinal center formation and termination

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Pages 2183-2184 | Received 18 May 2015, Accepted 22 May 2015, Published online: 01 Jul 2015

Figures & data

Figure 1. Proposed model in which LKB1 acts as an on/off switch to sequentially activate and inactivate B cells during a T cell dependent humoral immune response. In mature naïve B cells, LKB1 is active. Antigenic stimulation is proposed to inactivate LKB1, enabling cellular activation and the differentiation of highly proliferative GC B cells. To exit a GC, DNA double strand breaks during IG class switch recombination activate LKB1 to inactivate CRTC2 and promote the terminal differentiation of GC B cells into quiescent plasma cells.

Figure 1. Proposed model in which LKB1 acts as an on/off switch to sequentially activate and inactivate B cells during a T cell dependent humoral immune response. In mature naïve B cells, LKB1 is active. Antigenic stimulation is proposed to inactivate LKB1, enabling cellular activation and the differentiation of highly proliferative GC B cells. To exit a GC, DNA double strand breaks during IG class switch recombination activate LKB1 to inactivate CRTC2 and promote the terminal differentiation of GC B cells into quiescent plasma cells.

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