Figures & data
Figure 1. Proposed model in which LKB1 acts as an on/off switch to sequentially activate and inactivate B cells during a T cell dependent humoral immune response. In mature naïve B cells, LKB1 is active. Antigenic stimulation is proposed to inactivate LKB1, enabling cellular activation and the differentiation of highly proliferative GC B cells. To exit a GC, DNA double strand breaks during IG class switch recombination activate LKB1 to inactivate CRTC2 and promote the terminal differentiation of GC B cells into quiescent plasma cells.
![Figure 1. Proposed model in which LKB1 acts as an on/off switch to sequentially activate and inactivate B cells during a T cell dependent humoral immune response. In mature naïve B cells, LKB1 is active. Antigenic stimulation is proposed to inactivate LKB1, enabling cellular activation and the differentiation of highly proliferative GC B cells. To exit a GC, DNA double strand breaks during IG class switch recombination activate LKB1 to inactivate CRTC2 and promote the terminal differentiation of GC B cells into quiescent plasma cells.](/cms/asset/fe3a5b8d-4a1e-4af5-b85a-ab355b17a8bc/kccy_a_1056610_f0001_oc.gif)