Figures & data
Figure 1. Schematic representation of the interplay between SIRT6 and TET enzymes during ESC differentiation. The expression of the core pluripotent genes Oct4 and Sox2 is directly repressed by SIRT6-dependent deacetylation of H3K9ac and H3K56ac. This SIRT6-dependent activity controls OCT4:SOX2 heterodimer from over-activating the expression of TET enzymes, which then produce 5hmC at neural-related genes, thereby promoting development of the neuroectoderm germ layer. In the absence of SIRT6, elevated levels of acetylated H3K9 and H3K56 trigger the upregulation of OCT4 and SOX2, which in-turn over-activate expression of TET enzymes resulting in elevated levels of 5hmC at neural-related genes and consequently increasing neuroectoderm development.
