Figure 1. Mechanism of EMT induction derived from signaling network analysis validated in the mouse model. In Wild type EMT program is inhibited at the level of Notch and EMT genes by microRNAs activated by p53 family. Notch↑/p53↓ results in EMT genes induction, stabilised by WNT pathway. Phenotypes observed in single and double mutants: Notch↑ proliferative adenomas; p53↓ vulnerable to cancer; Notch↑/p53↓ proliferate, EMT, metastasize.
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