Figure 1. Responses to (6–4)PP. Most UVC-induced (6–4)PP (red triangle) will be repaired by NER. Unrepaired (6–4)PP are skipped by processive replication, necessitating to invoke error-prone TLS. Inadvertent TLS errors are excised by post-TLS repair. The resulting ss(6–4)PP patches induce checkpoint signaling and, during the subsequent cell cycle, can collapse (not shown). Error-free filling of the gaps induced by post-TLS repair mitigates the mutagenicity of UVC.
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