OCT4A and the DNA damage response

Figures & data

Figure 1. Cell-autonomous events in PA-1 cells treated with etoposide, based on Huna et al.² The G2/M-arrested transition state (OCT4A[+]/p21^Cip1[+]) has characteristics of both self renewal and senescence. OCT4A suppresses p21^Cip1 and senescence while enhancing mitotic recovery. Note the reported roles of p53 in both promoting and blocking senescence⁴ and of AMPK in activating the p53 axis in response to DNA damage.⁵

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