Figure 1. The figure shows in the upper part the main p27Kip1 structural domains and their putative roles. At the bottom, the missense mutations so far identified are reported. The corresponding human neoplasia where they have been identified are also listed. mNPAP60, mouse Nuclear Pore Associated Protein. Nuc (nucleus) and Cyt (Cytosol). AIP− (AIP gene mutation-negative). The arrows show the putative interacting residues.
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