Figures & data
Figure 1. Dual Functions of Topo II. Top: Strand Passage Reaction: (1) G-segment DNA binds at catalytic core, (2) T-segment DNA captured by N-gate, (3) G-segment cleavage and T-segment passage, (4) G-segment re-ligation and T-segment release. Middle: Domain structure (colors match domains above). C-Terminal Domain (CTD) has not been crystalized, but emanates from the lowest portion of the C-gate. Bottom: CTD functions in protein recruitment to chromatin and kinetochores via SUMOylated (S) and phosphorylated (P) residues.
