Figure 1. Ligand-bound, ubiquitinated EGFR are activated and signal at the plasma membrane. Post-internalisation they undergo ESCRT-mediated sorting to ILVs of MVBs that separates them from non-ubiquitinated recycling receptors and promotes their lysosomal degradation. Stress-induced non-ubiquitinated EGFR are activated post-internalisation and sequestered on ILVs of a separate subtype of signaling MVBs by the action of p38, WASH complex and ESCRT/ALIX.
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