Figures & data
Figure 1. Proposed model in which LRRK1 is activated by sequential phosphorylation of PLK1 and CDK1 at the centrosome and then phosphorylates CDK5RAP2, leading to the promotion of CDK5RAP2–γTuRC complex formation and the activation of γTuRC. Consequently, spindle orientation is properly regulated by the interaction between the cell cortex and astral MTs emanating from the centrosome at metaphase.
![Figure 1. Proposed model in which LRRK1 is activated by sequential phosphorylation of PLK1 and CDK1 at the centrosome and then phosphorylates CDK5RAP2, leading to the promotion of CDK5RAP2–γTuRC complex formation and the activation of γTuRC. Consequently, spindle orientation is properly regulated by the interaction between the cell cortex and astral MTs emanating from the centrosome at metaphase.](/cms/asset/7d65aece-b3e8-48e1-88ef-221d31434cdb/kccy_a_1093446_f0001_c.gif)