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EDITORIALS: CELL CYCLE FEATURES

LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

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Pages 3349-3350 | Received 26 Aug 2015, Accepted 31 Aug 2015, Published online: 13 Nov 2015

Figures & data

Figure 1. Proposed model in which LRRK1 is activated by sequential phosphorylation of PLK1 and CDK1 at the centrosome and then phosphorylates CDK5RAP2, leading to the promotion of CDK5RAP2–γTuRC complex formation and the activation of γTuRC. Consequently, spindle orientation is properly regulated by the interaction between the cell cortex and astral MTs emanating from the centrosome at metaphase.

Figure 1. Proposed model in which LRRK1 is activated by sequential phosphorylation of PLK1 and CDK1 at the centrosome and then phosphorylates CDK5RAP2, leading to the promotion of CDK5RAP2–γTuRC complex formation and the activation of γTuRC. Consequently, spindle orientation is properly regulated by the interaction between the cell cortex and astral MTs emanating from the centrosome at metaphase.

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