Figure 1. Model for Esc2 role in facilitating recombination at sites of perturbed replication. Esc2 binds stalled replication forks and interacts via its SUMO-like domains (SLDs) with Srs2 and Slx5/8. This guides Slx5/Slx8-mediated proteasome-dependent degradation of the anti-recombinase Srs2, enabling Rad51 filament formation and recombination-mediated DNA damage tolerance.
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